American Horror Story: Hotel is set in the Hotel Cortez, an enigmatic, six-story, art-deco hotel based in Los Angeles. The Countess, the owner of the hotel, tries to protect herself and her children from the fury of her past lover that seeks revenge on her, as well as John Lowe, a Los Angeles homicide detective on the task-force for a series of grisly murders that lead him in the direction of the hotel. Room 64 was originally used as Mr. March’s office when he first built the hotel in 1925. Detective Lowe receives a call from someone claiming responsibility for a murder and directing him to Room 64.